The application value of the joint detection of Ig and hs-crp in children with hand, foot and mouth disease

ObjectiveTo investigate the clinical value and application research of immunoglobulin(Ig) and hypersensitive C reactive protein(hs-CRP) in children with hand, foot and mouth disease(HFMD).

MethodsSeventy-six children with HFMD(HFMD group) were treated with ribavirin, and subdivdied into the improvement group and invalid group according to the therapeutic effects.Eighty health physical examination children were set as the control group.The levels of Ig(IgA, IgG and IgM) and hs-CRP in HFMD group and control group were detected.The sensitivity and specificity of two indexes in the diagnosis and treatment of HFMD were evaluated, and the ROC curve was plotted for correlation analysis.

ResultsThe levels of IgA and IgG in HFMD group were lower than those in control group(P < 0.01).The levels of IgM and hs-CRP in HFMD group were higher than those in control group(P < 0.01).After the HFMD group were treated with ribavirin, 64 cases were improved, and 12 cases were invalid.The levels of IgA and IgG in improvement group were higher than those in invalid group(P < 0.05), and the levels of IgM and hs-CRP in improvement group were lower than those in invalid group(P < 0.01).The differences of the sensitivity and specificity of IgA, IgG, IgM and hs-CRP in the diagnosis of HFMD children were not statistically significant(P>0.05).The sensitivity and specificity of Ig combined with hs-CRP in the diagnosis of HFMD children were higher than those of single indicator(P < 0.05).

ConclusionsThe joint detection of Ig and hs-CRP plays auxiliary screening function in the early diagnosis of HFDH, can identify the severity and development and guide the clinical treatment, and has high clinic value.It is worthy of promoting.