ObjectiveTo explore the relationship between the optimal cut point of D-dimer(D-D) and risk factors in patients with acute ischemic stroke(AIS), and its value in evaluating prognosis.
MethodsA total of 48 AIS patients and 35 healthy people were divided into the observation group and control group, respectively.The levels of D-D, homocysteine(Hcy), lipoprotein ALp(a), total cholesterol(TC), triglycerol(TG) and hypersensitive C reactive protein(hs-CRP) were detected in two groups.SPSS software 21.0 was used to analyze the receiver operating characteristic(ROC) curve, and predict the risk factors of AIS.The AIS was analyzed using non-conditional logistic regression model.
ResultsThe differences of the levels of D-D, Hcy, Lp(a), hs-CRP and TG between two groups were statistically significant(P < 0.05~P < 0.01).The area under the ROC curve of D-D was the highest, which was 0.966.The critical cut-off value of risk factors in AIS patients was 1.04 mg/L, and the diagnostic sensitivity and specificity were 87.5% and 97.1%, respectively.Multiple logistic regression analysis showed that D-D, Lp(a) and Hcy were the independent risk factors of AIS patients, and their relative risk coefficients were 15.000, 13.800 and 11.825, respectively.There was not correlation between D-D level and hypertension, TG(P>0.05), and the D-D level was positively correlated with the levels of Hcy, Lp(a) and hs-CRP(P < 0.05).With the increasing of D-D level, the proportion of AIS patients with poor prognosis increased.
ConclusionsD-D is a better predictor in the prediction of risk factors of AIS patients, the optimal predicted threshold is 1.04 mg/L.The increasing of D-D level is one of the independent risk factors of AIS, which can increase the risk of AIS.
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