Clinical characteristics and maternal and infant outcomes in patients with pregnancy complicated with pulmonary artery hypertension

ObjectiveTo investigate the clinical characteristics of patients with different degrees of pulmonary artery hypertension(PAH) during pregnancy, and analyze the maternal and infant outcomes.

MethodsAccording to the level of pulmonary systolic pressure(SPAP), 75 patients with pregnancy complicated with PAH were divided into the mild group(36 cases), moderate group(21 cases) and severe group(18 cases).The cardiac function grading, auxiliary examination indexes and maternal and infant outcomes among three groups were compared.

ResultsThe differences of the cardiac function grading, and levels of brain natriuretic peptide and SPAP among three groups were statistically significant(P < 0.01), and the differences of the myocardial enzymes and left ventricular ejection fraction among three groups were not statistically significant(P>0.05).The differences of the proportion of transferring to ICU among three groups were statistically significant(P < 0.01), and the differences of the pregnancy outcomes, delivery mode and anesthesia mode among three groups were not statistically significant(P>0.05).The differences of the gestational age, neonatal body mass, neonatal asphyxia and proportion of transferring to NICU among three groups were statistically significant(P < 0.01).

ConclusionsThe cardiac function grading, BNP and SPAP are related to the severity of PAH.The severity of PAH may affect the maternal and infant outcomes, and the clinical intervention should be conducted as early as possible.