Correlation study between the levels of serum interleukin 6, endothelin 1 and nitric oxide, and hyperhomocysteinemia

ObjectiveTo study the correlation between the serum homocysteine(HCY), and interleukin 6(IL-6), endothelin 1(ET-1) and nitric oxide(NO) in patients with coronary heart disease(CHD).

MethodsOne hundred and sixty with CHDincluding 64 cases with hyperhomocysteinemia(HHCY group) and 96 cases with normal homocysteine(non-HHCY group), and 40 patients with negative coronary angiography were divided into the observation group and control group, respectively.The serum levels of IL-6, ET-1 and NO in all cases were measured, and the difference of which was compared.

ResultsThe incidence rate of HHCY in observation group was higher than that in control group(P < 0.01).The differences of the BMI, smoking, IL-6, NO and ET-1 between HHCY group and non-HHCY group were statistically significantly(P < 0.01).In HHCY group, HCY was positively correlated with IL-6 and ET-1(P < 0.01);and HCY was negatively correlated with NO(P < 0.01).The incidence rate of acute coronary syndrome in HHCY group was significantly higher than that in non-HHCY group(P < 0.01).

ConclusionsHyperhomocysteinemia is related to the clinical severity of CHD.Hyperhomocysteinemia may be involved in the pathogenesis of CHD by promoting the inflammatory reaction to lead to the dysfunction of vascular endothelium.