Clinicopathologic analysis of multifocal papillary thyroid carcinoma

ObjectiveTo explore the clinicopathologic characteristics of multifocal papillary thyroid carcinoma(MPTC), and its relationship with invasion.

MethodsA total of 367 papillary thyroid carcinoma(PTC) cases confirmed by pathology treated with total or subtotal thyroidectomy from 2013 to 2018 were divided into the multifocal group and single focal group.The clinical pathological characteristics in two groups were retrospectively analyzed.

ResultsCompared with the single focal group, the proportions of male and non-simple micro cancer cases with tumor lesion ≥ 1 cm, rate of cervical lymph node metastasis, and proportion of cases with extra-glandular tissue invasion were higher in multifocal group(P < 0.05 to P < 0.01).The proportion of cases with simple micro cancer was lower(P < 0.01), and the differences of the proportion of cases with ≥ 45 years old complicated with or without nodular goiter and Hashimoto's thyroiditis were not statistically significant(P>0.05).

ConclusionsThe multiple lesion is one of the clinical features of PTC, which is more likely to happen cervical lymph node metastasis and extrathyroid invasion, and more aggressive.