Effect of the cytotoxic drugs on the morphology of hematologic tumor cells, and its clinical significance

ObjectiveTo observe the cytotoxic drugs on the morphology of hematologic tumor cells, and its clinical significance.

MethodsThe bone marrow smears of 58 patients with hematological tumors treated with cytotoxic drugs were collected.Bone marrow smears were stained using Wright's staining, and observed under low power microscopy to judge the degree of proliferation.The morphological changes of cells and abnormal cells were observed under oil microscopy.

ResultsAmong 58 patients treated with cytotoxic drugs, the morphological changes in one or more lines of bone marrow cells in 52 cases(89.66%) were found, which included the morphological changes of erythrocyte in 36 cases(62.07%), the morphological changes of granulocyte in 49 cases(84.48%), the morphological changes of mega-cell in 22 cases(37.93%) and no significant change in 6 cases(10.34%).The results of hematology examination in 58 patients showed that the complete remission in 39 cases(67.24%), partial remission in 12 cases(20.69%) and no remission in 7 cases(12.07%) were identified.The cell morphology changes in one or more lines in patients with complete remission and partial remission were found, and no cell morphology change in 1 case with no remission was detected.

ConclusionsAfter the hematological tumor patients were treated with cytotoxic drugs, the adverse reactions can be detected as early as possible through the effects and changes of cell morphology, which has certain clinical significance in developing more scientific and effective treatment schemes and improving the quality of life in hematological tumor patients.