Effect of clopidogrel complicated with biaspion in the treatment of acute cerebral infarction

ObjectiveTo explore the effects of clopidogrel complicated with biaspion in the treatment of acute cerebral infarction, and on the expression levels of alpha granule membrane glycoprotein(CD62p) and lysosomal granule membrane glycoprotein(CD63).

MethodsThe positive rates of CD62p and CD63 in two groups were detected before and after treatment, and the clinical efficacy was evaluated.

ResultsThe differences of the positive rates of CD62p and CD63 between two groups before treatment were not statistically significant(P>0.05), and the differences of the positive rates of CD62p and CD63 in two groups between before treatment and after 1 week of treatment were not statistically significant(P>0.05).The differences of CD62p, CD63 and NIHSS scores in two groups between after and before treatment, and between after 3 and 2 weeks of treatment were statistically significant(P < 0.01).There was no statistical significance in total incidence rate of adverse event between two groups(P>0.05).

ConclusionsThe overall efficacy of 100 mg baiaspirin combined with 50 mg clopidogrel in the treatment of cerebral infarction of elderly patients is better than that of 150 mg baiaspirin.The monitoring of CD63 and CD62p can be an important index for anti-platelet therapy.