Study on norepinephrine activating Akt signaling pathway in breast cancer under anxiety state

ObjectiveTo explore the effects and mechanism of norepinephrine in breast cancer under anxiety state.

MethodsTwenty C57BL/6 mice were divided into the control group and model group.The mice models with anxiety tumor-bearing were established using inoculation of tumor cells and experimental stimulation.The serum level of norepinephrine was detected, and the tumor volume was measured after modeling.The proliferation, migration, invasion, cell cycle distribution and activation of Akt signaling pathway of MDA-MB-231 breast cancer cells treated with norepinephrine were detected.

ResultsThe tumor volume in model group was significantly larger than that in control group (P < 0.05), and the serum concentration of norepinephrine significantly increased (P < 0.01), which was correlated with the anxiety degree (r=0.78).Norepinephrine enhanced the proliferation, migration and invasion of MDA-MB-231 cells, promoted DNA replication, and activated the Akt signaling pathway.

ConclusionsNorepinephrine activates the Akt signaling pathway to promote the development of breast cancer under state anxiety.