Correlations of mild hyperuricemia with GFR and ACR

ObjectiveTo investigate the association between asymptomatic mild hyperuricemia (HUA) and estimated glomerular filtration rate (eGFR), urinary albumin-creatinine ratio (ACR) among community population in South China, and analyze the adverse effects of mild hyperuricemia on kidney.

MethodsA cross-sectional study was conducted among 1 276 community residents in Zhuhai Guangdong province.The differences of eGFR and ACR in male, female and the whole population between mild hyperuricemia group and normal group were compared.Whether the mild hyperuricemia leading to the eGFR decreasing and mild ACR increasing or not was explored using the univariate, multivariate and stepwise logistic regression models.

ResultsAmong the female and whole population, the eGFR in mild hyperuricemia group was lower than that in normal group, and the results of univariate, multivariate and stepwise logistic regression models analysis showed that the mild hyperuricemia was a risk factor of the eGFR decreasing.The differences of ACR mild between mild hyperuricemia group and normal group among the male, female and whole population were not statistically significant (P>0.05).Among whole population, the results of univariate logistic regression model analysis showed the mild hyperuricemia was a risk factor of mild ACR increasing.

ConclusionsThe asymptomatic mild hyperuricemia may have an adverse effect on the glomerular filtration function of the community population, especially the female population in South China.