Study on the correlation between glomerular filtration rate estimated by modified simplified MDRD equation and pathological damage caused by of IgA nephropathy

ObjectiveTo investigate the correlation between glomerular filtration rate estimated by modified simplified MDRD equation(MDRD-eGFR) and pathological damage caused by IgA nephropathy.

MethodsThe clinical and pathological data and modified simplified MDRD-eGFR in patients with IgA nephropathy were retrospectively analyzed.The renal pathological injury was graded according to Katafuchi semi-quantitative score standard and Lee's grading standard.

ResultsWith the aggravation of pathological injury, the level of modified simplified MDRD-eGFR decreased gradually(P < 0.05).The Katafuchi score, glomerulosclerosis, tubular interstitial injury and renal vasculopathy were correlated with modified simplified MDRD-eGFR(P < 0.01).When the modified simplified MDRD-eGFR was more than or equal to 90 mL·min^-1·1.73 m^-2, the correlation disappeared, but the patients had some degree of pathological injury.

ConclusionsThe modified simplified MDRD-eGFR is closely related to the renal pathological damage in IgA nephropathy.When the modified simplified MDRD-eGFR is less than 90 mL·min^-1·1.73 m^-2, the prediction value of which in renal tubulointerstitial injury is great.