Characteristics of patients with hyperlipidemic acute pancreatitis, and the value of c-reactive protein in assessing disease severity

ObjectiveTo explore the clinical features of hyperlipemic acute pancreatitis(HLAP), and value of C reactive protein(CRP) in the evaluation of severity and prognosis of HLAP.

MethodsThe clinical data of 103 patients with acute pancreatitis were retrospectively analyzed, the patients were divided into the HLAP group(32 cases) and non-HLAP group(71 cases), and the clinical features between two groups were compared.The HLAP group was subdivided into the HLAP1 group(mild disease, 22 cases) and HLAP2 group(severe disease, 10 cases) according to the severity of disease.The serum levels of CRP in HLAP1 and HLAP2 groups on the 1st, 3rd, 5th and 7th day of admission were detected.The value of CRP level in the evaluation of severity of HLAP was investigated using ROC curve.

ResultsCompared with the non-HLAP group, the fasting blood glucose and triglyceride(TG) were higher(P < 0.01), and the levels of CRP, mean age and serum AMY, Ranson score, and Apache Ⅱ score were lower in HLAP group(P < 0.05 to P < 0.01).On the 1st, 3rd, 5th and 7th day of admission, the serum levels of CRP in HLAP1 group were lower than that in HLAP2 group(P < 0.05 to P < 0.01).The serum CRP levels in two groups on the 3rd day of admission were the highest(P < 0.01), and then gradually decreased(P < 0.01).The incidence rate of fatty liver in HLAP group(28.1%) was higher than that in non-HLAP group(11.3%)(P < 0.05).The ROC curve evaluation indicated that the AUC area of CRP in the evaluation of HLAP severity was 0.905(P < 0.01), and the 95% CI was 0.782~1.000.

ConclusionsThe onset age of HLAP tends to be younger, and the incidence rate of fatty liver is high.CRP can be used as the evaluation index of the severity of HLAP, and has economy, convenience and feasibility in evaluating the prognosis of HLAP.