Effect of dexmedetomidine on the hemodynamics in elderly hypertensive patients treated with endotracheal intubation under general anesthesia

ObjectiveTo study the effects of dexmedetomidine on hemodynamics in elderly hypertensive patients treated with endotracheal intubation under general anesthesia.

MethodsSixty elderly hypertensive patients treated with endotracheal intubation under general anesthesia were divided into the control group(treatment with 0.9% sodium chloride solution) and observation group(treatment with dexmedetomidine)(30 cases each group).The anesthesia time, operation time, recovery time, extubation time, blood pressure and heart rate of different time points, and incidence rate of adverse reactions were compared between two groups.

ResultsThere was no statistical significance in anesthesia time and operation time between two groups(P>0.05), and the recovery time and extubation time in observation group were significantly shorter than those in control group(P < 0.05 and P < 0.01).There was no statistical significance in blood pressure and heart rate between two groups before entering room and before 1 min of intubation(P>0.05).The blood pressure and heart rate in observation group at intubation, before and after 1 min of intubation were significantly lower than those in control group(P < 0.01).There was no statistical significance in the incidence rates of dry outlet, hypotension, chills, bradycardia and delayed recovery between two groups(P>0.05).

ConclusionsAmong elderly hypertensive patients treated with endotracheal intubation under general anesthesia, the dexmedetomidine anesthesia can reduce the blood pressure and heart rate fluctuation, promote hemodynamic stability, does not cause serious adverse reactions, and is safe.