Change of the serum level of cyclophilin B and its diagnostic value in patients with early gastric cancer

ObjectiveTo investigate the changes of the serum level of cyclophilin B(CypB) and its auxiliary diagnosis value in patients with early gastric cancer, and provide reference in the clinical diagnosis and treatment of early gastric cancer.

MethodsForty-nine patients with early gastric cancer and 45 health examiners were divided into the observation group and control group, respectively.The serum levels of CypB, carcinoembryonic antigen(CEA) and carbohydrate antigen-199(CA-199) in two groups were detected using enzyme linked immunosorbent assay.The early diagnostic value of each index in early gastric cancer patients was evaluated, and the correlation of serum level of CypB with CEA and CA-199 in patients with early gastric cancer was analyzed.

ResultsThe difference of general data between two groups was not statistically significant(P>0.05).The serum levels of CypB, CEA and CA-199 in observation group were significantly higher than those in control group(P < 0.01).The serum level of CypB in observation group was significantly positively correlated with CEA and CA-199(P < 0.05).The ROC curve analysis showed that when 4.030 ng/mL was set as the cut-off point, the sensitivity and specificity of CypB in the diagnosis of early gastric cancer were 76.36% and 75.51%, respectively, the area under the curve was 0.766, and the diagnostic efficacy of CypB was better than that of CEA and CA-199.

ConclusionsThe serum level of CypB in patients with early gastric cancer increases, which has certain value for auxiliary diagnosis.