Scavenging effect of edaravone on oxygen free radical in acute cerebral infarction patients treated with recombinant tissue plasminogen activator

ObjectiveTo observe the scavenging effects of edaravone on oxygen free radical in acute cerebral infarction patients treated with recombinant tissue plasminogen activator.

MethodsSixty patients with acute cerebral infarction were randomly divided into the observation group and control group(30 cases each group).All patients were treated with routine treatment method of cerebral infarction combined with recombinant tissue plasminogen activator, and the observation group were additionally treated with edaravone.The serum levels of Hydroxyl radical(OH), nitric oxide(NO), lipid peroxide(PLO), peroxide dismutase(SOD), advanced oxidative protein product(AOPP) and malondialdehyde(MDA) in two groups were measured before and after treatment.The daily living ability and neurological deficit in two groups were evaluated using ADL and NIHSS.

ResultsBefore treatment, the differences of the levels of OH, NO, PLO, SOD, AOPP, MDA, ADL and NIHSS scores between two groups were statistically significant before treatment(P>0.05).After treatment, the levels of OH, NO and PLO in two groups were significantly lower than those before treatment(P < 0.01), and the serum levels of OH, NO and PLO in observation group were significantly lower than those in control group(P < 0.01).After treatment, the serum levels of SOD, AOPP and MDA in two groups were significantly lower than those before treatment(P < 0.01), and the serum levels of SOD, AOPP and MOD in observation group were significantly lower than those in control group(P < 0.01).After treatment, the ADL scores in two groups significantly increased compared before treatment(P < 0.01), and the ADL score in observation group were significantly higher than that in control group(P < 0.01).After treatment, the NIHSS scores in two groups decreased compared before treatment(P < 0.01), and the NIHSS score in observation group were significantly lower than that in control group(P < 0.01).

ConclusionsThe recombinant tissue plasminogen activator combined with edaravone in the treatment of acute cerebral infarction can effectively scavenge oxygen free radical, reduce oxidative stress injury, and improve daily living ability.