Correlation between serum biochemical indicators and severity of acute cerebral infarction

ObjectiveTo investigate the serum levels of uric acid(UA), lipoprotein aLP(a), total bilirubin(TB), homocysteine(HCY), and cystatin C(Cyc C) in acute cerebral infarction, and analyze the correlation of which with severity of cerebral infarction.

MethodsOne hundred and ninety-eight patients with acute cerebral infarction and 150 patients without cerebral vascular disease were divided into the cerebral infarction group and control group, respectively.The serum levels of UA, LP(a), TB, HCY and Cyc C were detected, and the neurological function was scored according to NIHSS in two groups.The correlation between biochemical indicators and NIHSS scores were analyzed using the binary distance correlation analysis.

ResultsThe serum levels of UA, TB, HCY and Cyc C in cerebral infarction group were higher than those in control group(P < 0.05 to P < 0.01).The difference of the level of LP(a) between two groups was not statistically significant(P>0.05).The serum levels of UA and LP(a) were negatively correlated with NIHSS scores(P < 0.01 and P < 0.05), and there were not obvious correlation between the serum levels of TB, HCY, Cyc C and NIHSS scores(P>0.05).

ConclusionsThe serum levels of UA, TB, HCY and Cyc C increase in acute cerebral infarction.UA and LP(a) may play a protective role after cerebral infarction.