ObjectiveTo analyze the level and abnormality rate of myocardial enzyme creatine kinase isozyme (CKMB) in children with hand, foot and mouth disease complicated with myocardial damage, and explore the influencing factors of children's hand, foot and mouth disease complicated with myocardial damage.
MethodsA total of 100 children with hand, foot and mouth disease were set as the observation group, and 56 cases with hand, foot and mouth disease and 44 cases with hand, foot and mouth disease complicated with myocardial damage were subdivided into the group A and group B, respectively.Fifty healthy children in the same period were set as the control group.The levels of CKMB between before and after treatment in group A and group B were compared, and which was compared with the control group.At the same time, the general data and laboratory indexes in group A and group B were observed, and the related factors influencing the children with hand, foot and mouth disease complicated with myocardial damage were analyzed using multivariate logistic regression method.
ResultsBefore treatment, the activity and abnormal rate of CKMB in observation group were significantly higher than those in control group (P < 0.01), and the activity and abnormal rate of CKMB in observation group after treatment were significantly lower than those before treatment (P < 0.01).After treatment, there was no statistical significance in the activity and abnormal rate of CKMB between the observation group and control group (P>0.05).The results of single factor analysis showed that the fever rate, duration of fever, and levels of CRP, WBC and CKMB in group A were higher than those in group B(P < 0.05 to P < 0.01), and there was no statistical significance in heart rate abnormality, blood pressure abnormality, respiratory frequency, rash site, duration of rash, and levels of lymphocyte, RBC, HBG and PLT between group A and group B(P>0.05).The results of multivariate logistic regression analysis showed that the fever, and levels of WBC, CRP and CKMB were the risk factors of myocardial damage.
ConclusionsFor children with hand, foot and mouth disease, the level of CKMB increasing hints the risk of myocardial injury.Strengthening the detection of myocardial enzymes in children with hand, foot and mouth disease, and early intervening the children with abnormal detection result, especially for the children with fever symptom, and levels of WBC, CRP and CKMB increasing, can more effectively prevent and reduce the occurrence of myocardial damage in clinic.
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