Change and effect of norepinephrine and interleukin-6 in HFMD children infected by EV71

ObjectiveTo observe the levels of norepinephrine(NE) and interleukin-6(IL-6) during the stage Ⅱ, Ⅲ and Ⅳ hand foot mouth disease(HFMD) children infected by enterovirus 71(EV71), and investigate the correlation of levels of NE and IL-6 with EV71 infection.

MethodsThe differences of the clinical presentation and laboratory examination among stage Ⅱ, Ⅲ and Ⅳ HFMD children infected by EV71 and healthy children were compared.The levels of NE and IL-6 in different period were detected, and the correlation of levels of NE and IL-6 with disease progression were analyzed.

ResultsWith the progression of HFMD, the proportions of EV71 infection children with duration 72 h of high fever, poor spirit, vomiting, irritability, dysphasia, rapid heart rate, capillary refill time >2 s, white blood cell >15×10⁹/L and glucose >8.3 mmol/L gradually increased(P < 0.05 to P < 0.01).The levels of NE and IL-6 in EV71 infection stage Ⅱ, Ⅲ and Ⅳ children were significantly higher than those in healthy children, and which gradually increased with the increasing of EV71 infection staging(P < 0.01).The results of Pearson correlation analysis showed that the level of IL-6 was positively correlated with NE level in EV71 infection children(P < 0.01).

ConclusionsThe levels of NE and IL-6 in HFMD increasing with the progression of EV71 infection staging may be an important factor for the disease progression after EV71 infection, which hints that clinicians can evaluate the children's condition by analyzing the levels of NE and IL-6.