Value of B type natriuretic peptide combined with C reactive protein in the evaluation of chronic obstructive pulmonary disease complicated with cardiac insufficiency

ObjectiveTo investigate the value of B type natriuretic peptide(BNP) combined with C reactive protein(CRP) in the evaluation of chronic obstructive pulmonary disease(COPD) complicated with cardiac insufficiency.

MethodsSixty COPD patients complicated with cardiac insufficiency were divided into group A(left ventricular dysfunction) and group B(right cardiac insufficiency), and 53 COPD patients without cardiac insufficiency were set as the control group.The levels of BNP and CRP were measured in three groups.

ResultsThe level of LVEF in group A was lower than that in control group(P < 0.01), and the left ventricular diameter in group A was higher than that in control group(P < 0.01).The pulmonary artery pressure and right ventricular diameter in group B were higher than those in control group(P < 0.01).The levels of BNP and CRP in group A and group B were significantly higher than those in control group(P < 0.01), and the level of BNP in group A was higher than that in group B(P < 0.01).The levels of BNP and CRP in group A and group B after treatment were significantly lower than those before treatment(P < 0.05 to P < 0.01).The levels of BNP and CRP in group A were negatively correlated with LVEF level(P < 0.05), and the levels of BNP and CRP in group B were positively correlated with pulmonary artery pressure(P < 0.05).

ConclusionsThe levels of BNP and CRP can help to identify the cardiac insufficiency in COPD patients.