Clinical effect analysis of the topical injection of methotrexate guided by ultrasound combined with oral mifepristone in the treatment of cesarean scar pregnancy

ObjectiveTo investigate the efficacy and safety of the local injection of methotrexate guided by ultrasound combined with oral mifepristone in the treatment of cesarean scar pregnancy.

MethodsFifty-four patients with cesarean scar pregnancy were randomly divided into the control group and observation group.The control group was treated with oral mifepristone, and the observation group was treated with the local injection of methotrexate guided by ultrasound combined with oral mifepristone based on the control group.At the same time, two groups were treated with cesarean curettage.The clinical therapeutic effect, adverse reactions and effective rate of treatment between two groups were statistically analyzed.

ResultsThe time of hospitalization, time of hCG turning negative, time of disappearance of internal lesions and time of menstrual recover in observation group were better than those in control group(P < 0.01), and the intraoperative blood loss in observation group was less than that in control group(P < 0.01).The incidence rate of total adverse reactions, such as palpitation, nausea and abdominal pain, in observation group was lower than that in control group(P < 0.01), and the effective rate of treatment in observation group was higher than that in control group(P < 0.05).

ConclusionsThe local injection of methotrexate guided by ultrasound combined with oral mifepristone in the treatment of cesarean scar pregnancy can effectively improve the clinical efficacy, and reduce the incidence rate of adverse reactions, which is worthy of promotion in clinical practice.