Effect of bifidobacterium on plasma level of peptide YY and insulin resistance in type 2 diabetic rats

ObjectiveTo observe the effects of bifidobacterium on the plasma level of peptide YY (YY) and HOMA-IR in type 2 diabetic(T2DM) rats.

MethodsThirty SD male STZ model rats aged 9 weeks were divided into the normal control group(group N), diabetes mellitus group(group T2DM), high dose group and low dose group according to the gavage dose of bifidobacteria.After 6 weeks of continuous bifidobacterium administration, the levels of fasting blood sugar(FBS) were measured in all rats.The serum levels of PYY, HbA1c, fasting insulin(FINS) and blood lipids in four groups were measured after death, the HOMA-IR was calculated to compare the differences of the above indexes among four groups.

ResultsThe levels of HbA1c, FBS, FINS, HOMA-IR and triglyceride in high-dose group and low-dose group were significantly lower than those in group T2DM(P < 0.01), and higher than those in group N(P < 0.05 to P < 0.01).The serum levels of PYY in high-dose group and low-dose group were significantly higher than that in group T2DM(P < 0.01), but lower than that in group N(P < 0.01).The differences of the above indictors between high-dose group and low-dose group were not statistically significant(P>0.05), and the level of PYY was negatively correlated with HOMA-IR(r=-0.783, P < 0.01).

ConclusionsBifidobacterium can decrease the levels of HbA1c, FBS, FINS, TG and HOMA-IR, and increase the level of PYY in T2DM rats.