Effect of high-dose ambroxol hydrochloride injection on postoperative lung function recovery in lung cancer patients

ObjectiveTo explore the therapeutic effects of high-dose ambroxol hydrochloride injection on postoperative lung function recovery in patients with lung cancer.

MethodsNinety patients with non-small-cell lung cancer(NSCLC) were randomly divided into the control group and observation group according to the digital table method.All patients were treated with thoracoscopic radical surgery.Before 1 day and after 5 days of operation, the control group and observation group were intravenously treated with the conventional dose of ambroxol(60 mg/d) and high-dose ambroxol(500 mg/d), respectively.The hospital-related indicators, lung function and serum levels of inflammatory factors before and after surgery, and complications were compared between two groups.

ResultsThe postoperative pulmonary function indexes and score of expectoration degree of two groups after operation were significantly lower and higher than those before operation, respectively(P < 0.01).The PEF25 level and score of expectoration degree in observation group after 5 days of operation were significantly higher and lower than those in control group(P < 0.01 and P < 0.05).The serum levels of IL-6, IL-8 and CRP in two groups after 1 day of operation significantly increased compared with before operation, the serum levels of IL-6, IL-8 and CRP in observation group after 5 days of operation were significantly higher and lower than those before operation and after 1 day of operation, respectively, and the serum levels of IL-6, IL-8 and CRP in observation group after 1 day and 5 days of operation were significantly lower than those in control group(P < 0.01).The hospitalization time and antibacterial use time in observation group were significantly lower than those in control group(P < 0.01).There was no statistical significance in incidence rate of complications between two groups(P < 0.05).

ConclusionsThe perioperative application of high-dose ambroxol can reduce lung injury, promote recovery of lung function, improve postoperative inflammatory response, and reduce antibacterial use time in patients with radical lung cancer.