Correlation analysis of the serum levels of IGF-Ⅰ and IGF-Ⅱ with Ki-67 and EGFR expression in patients with uterine leiomyoma

ObjectiveTo investigate the correlations between the serum levels of insulin growth factor-Ⅰ and Ⅱ(IGF-Ⅰ, IGF-Ⅱ), and expression levels of nuclear proliferation-related antigen(Ki-67) and epidermal growth factor receptor(EGFR) in patients with uterine leiomyoma.

MethodsNinety-three patients with uterine leiomyoma and 90 patients with adenomyosis were divided into the observation group and control group, respectively.The serum levels of IGF-Ⅰ and IGF-Ⅱ, and expression levels of Ki-67 and EGFR in uterine tissue in two groups were recorded.The correlations between the serum levels of IGF-Ⅰ and IGF-Ⅱ, and expression levels of Ki-67 and EGFR were analyzed.

ResultsThe serum levels of IGF-Ⅰ and IGF-Ⅱ, and positive rates of Ki-67 and EGFR in observation group were significantly higher than those in control group(P < 0.01).In the observation group, the serum levels of IGF-Ⅰ and IGF-Ⅱ in patients with positive Ki-67 and EGFR expression were significantly higher than those in patients with negative Ki-67 and EGFR expression(P < 0.01).The results of the correlation analysis showed that the serum levels of IGF-Ⅰ and IGF-Ⅱ were significantly positively correlated with Ki-67 and EGFR expression(P < 0.01).

ConclusionsThere is a significant correlation between serum levels of IGF-Ⅰ and IGF-Ⅱ, and expression levels of Ki-67 and EGFR in cancer tissue of patients with uterine leiomyoma.