Change and clinical significance of the serum levels of Prdx1 and Prdx6 in sepsis patients

ObjectiveTo investigate the changes of serum levels of Prdx1 and Prdx6 in sepsis patients and their clinical significance.

MethodsThe serum levels of Prdx1 and Prdx6 in 55 patients with sepsis were determined by ELISA on the 1st, 3rd, 5th and 7th days of admission.The temperature, white blood cell count, platelet, alanine transaminase, creatinine, procalcitonin, C-reactive protein, scores of acute physiology and chronic health evaluation and sequential organ failure assessment and general data(gender, age, protopathy, infection site, pathogenic bacteria, norepinephrine use or mechanical ventilation) in all patients were analyzed at each point.

ResultsThe serum level of Prdx1 in septic shock patients was higher than that in sepsis patients(P < 0.05).There was no statistical significance in serum level of Prdx6 between two groups(P>0.05).The serum level of Prdx1 in patients with APACHEⅡ score ≥ 15 was significantly higher than that in patients with APACHEⅡ score < 15(P < 0.01), the difference of the serum level of Prdx6 between two groups was not statistically significant(P>0.05).The serum levels of Prdx1 in survival group on the 1st, 3rd, 5th and 7th days were significantly lower than that in death group at time passed(P < 0.01), and except the third day, the difference of the serum level of Prdx6 between two groups was not statistical significance(P>0.05).

ConclusionsThe serum levels of Prdx1 and Prdx6 in sepsis patients increase, which may become the molecular targets in the early diagnosis and treatment of sepsis.