Effect of low-dose of atorvastatin combined with ezetimibe in the treatment of hyperlipidemia in patients with ischemic stroke

ObjectiveTo investigate the efficacy and safety of low dose of atorvastatin combined with ezetimibe in the treatment of hyperlipidemia in patients with ischemic stroke, and analyze its effect in the secondary prevention of stroke.

MethodsThe clinical data of 128 patients with ischemic stroke complicated with hyperlipidemia were divided into the control group(treatment with taking lipid-lowering drugs for more than 6 months), atorvastatin group(treatment with 40 mg of atorvastatin) and combination group(20 mg of atorvastatin combined with ezetimibe).The levels of blood lipid before and after 6 months of treatment, and occurrence rates of ischemic stroke end event, cardiovascular event, peripheral vascular occlusion and other adverse reactions after 2 years of treatment were compared among three groups.

ResultsAfter 6 months of treatment, the levels of triglyceride(TG), total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in three groups were lower than those before treatment(P < 0.05 to P < 0.01), and the differences of the level of high-density lipoprotein cholesterol among three groups were not statistically significant(P>0.05).After treatment, the levels of TG, TC and LDL-C in atorvastatin group and combination group were significantly higher than those in control group(P < 0.01), and the differences of those between atorvastatin group and combination group were not statistically significant(P>0.05).The patients with hospitalization for recurrent ischemic stroke in atorvastatin group and combination group were significantly lower than that in control group(P < 0.05), and the difference of which between atorvastatin group and combination group was not statistical significance(P>0.05).The occurrence rates of cardiovascular event in atorvastatin group and combination group were significantly lower than that in control group(P < 0.05).There was no statistical significance of the incidence rate of adverse reaction between atorvastatin group and combination group(P>0.05).

ConclusionsThe low-dose of atorvastatin combined with ezetimibe can effectively and safely reduce the blood lipid level of the patients with ischemic stroke complicated with hyperlipidemia, especially complicated with hybrid hyperlipidemia, and provide a similar protective effect in the secondary prevention of stroke and reducing cardiovascular events.