Clinical application value of the serum levels of NSE, S100B and IL-6 in premature infants with brain injury

ObjectiveTo investigate the incidence rate and clinical manifestations of premature infants with white matter damage(WMD), and explore its correlation with the serum levels of neuron-specific enolase(NSE), S100B and interleukin 6(IL-6).

MethodsSixty preterm infants were divided into the WMD group(18 cases) and control group(42 cases, non-WMD) according to the results of cranial ultrasound and head MRI examination.The serum levels of S100B, NSE and IL-6 were detected using chemiluminescence after 24 h and 7 d of birth.

ResultsThe incidence rate of WMD in preterm infants was 29.03%.The proportion of convulsion, apnea and poor response in WMD group were higher than those in control group(P < 0.05).The levels of S100B, NSE and IL-6 in WMD group were higher than those in control group after 24 h and 7 d of birth(P < 0.05 to P < 0.01).The levels of S100B, NSE and IL-6 in two groups after 7 d of birth decreased, which was lower than those after 24 h of birth(P < 0.05 to P < 0.01).

ConclusionsThe serum levels of NSE, S100B and IL-6 are related to the severity of WMD.The levels of S100B, NSE and IL-6 in preterm infants with WMD significantly increase after 24 h of birth.The longer the levels of S100B and IL-6 elevating duration is, the more serious the disease is, and the higher the risk of death is, which has important guiding significance in the early diagnosis of WMD in preterm infants.