Advanced Search
    ZHAO Yu-li, LIU Yue-peng, HUANG Hou-qin, TAN Xiao. Effect of pulsed electric stimulation combined with curcumin on melanoma of foot back skin in mice[J]. Journal of Bengbu Medical University, 2019, 44(11): 1449-1452. DOI: 10.13898/j.cnki.issn.1000-2200.2019.11.004
    Citation: ZHAO Yu-li, LIU Yue-peng, HUANG Hou-qin, TAN Xiao. Effect of pulsed electric stimulation combined with curcumin on melanoma of foot back skin in mice[J]. Journal of Bengbu Medical University, 2019, 44(11): 1449-1452. DOI: 10.13898/j.cnki.issn.1000-2200.2019.11.004
    shu

    Effect of pulsed electric stimulation combined with curcumin on melanoma of foot back skin in mice

      Graphical Abstract
      • Abstract
    • Objective To observe the effects of pulsed electric stimulation combined with curcumin on melanoma of foot back skin in mice.
      Methods The B16-F10 mouse melanoma cells were subcutaneously injected into the C57/BL6 mouse dorsal foot to establish the dorsal melanoma model.The melanoma was treated with pulsed electric stimulation combined with curcumin, and the tumor size, growth and apoptosis were observed.
      Results The pulsed electric stimulation or combined with curcumin could inhibit the tumor growth of melanoma(P < 0.01), and the combined therapy was more effective(P < 0.05).The number of apoptotic cells increased after combined therapy(P < 0.05).
      Conclusions The model of dorsal foot melanoma is easy to observe the morphology and measure the volume of the tumor.The pulsed electric stimulation combined with curcumin can inhibit the growth of melanoma by inducing apoptosis, which is an effective treatment method for melanoma.
      • FullText(HTML)
    • loading
      • References (10)
      • Related Articles
    • Supplements (0)

    Catalog

      Turn off MathJax
      Article Contents

      /

      DownLoad:  Full-Size Img  PowerPoint
      Return
      Return