ObjectiveTo investigate the effects of selenium intervention on the clinical curativeeffect and oxidative/antioxidant system in Hashimoto thyroiditis(HT).
MethodsSixty cases with HT were randomly divided into the selenium group(group A) and levothyroxine group(group B), and further divided into the A1 and A2 subgroups(euthyroidism), and B1 and B2 subgroups(hypothyroidism).Patients in group A and B were both treated with levothyroxine replacement therapy.Besides, patients in group A received particular treatment of selenium geast.Thirty healthy people were set as the normal control group(NC group).The changes of the serum levels of selenium, TT3, TT4, TSH, thyroid peroxidase antibody(TPOAb), thyroid globulin antibody(TgAb), oxidation index(MDA) and antioxidant index(GPX) in each group were analyzed before and after treatment.And the corretations of the indexes were also analyzed.
ResultsBefore treatment, the serum levels of selenium in HT patients were significantly lower than that in NC group(P < 0.05), and which in hypothyroidism group were lower than that in euthyroidism group(P < 0.05).After treatment, the serum levels of selenium in group A increased greatly(P < 0.05), and there was not obvious change in group B(P>0.05).After treatment, the serum levels of TSH in A2 and B2 groups decreased greatly(P < 0.05), and the difference of the thyroid function in other groups was not statistically significant(P>0.05).After treatment, the levels of TPOAb and TgAb in group A decreased remarkably on the whole(P < 0.01), and the change of which in group B was not obvious(P>0.05).Before treatment, the concentration of MDA and GPX activity in HT patients were higher and lower than that in NC group, respectively(P < 0.05).After treatment, the total serum level of MDA and GPX activity in group A decreased and increased greatly, respectively(P < 0.05), and the changes of two indexes were not obvious in group B(P>0.05).Before treatment, the serum level of selenium was positively correlated with TT4(r=0.294, P < 0.05), and negatively correlated with TSH(r=-0.343, P < 0.01).There was not significant correlation among other indicators(P>0.05).
ConclusionsThe serum level of selenium in HT patients is lower than that in healthy people.The selenium yeast can reduce the levels of thyroid autoantibodies(TPOAb and TgAb), strengthen the antioxidant capacity, and reduce the oxidative damage in HT patients.The treatment effect of selenium combined with levothyroxine is superior to the single use of the latter.
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