ObjectiveTo investigate the prognostic value of comorbidities in patients with stable chronic obstructive pulmonary disease(COPD).
MethodsThe clinical data of 51 stable COPD patients were retrospectively analyzed, and the Charlson comorbidity index(CCI) was calculated.According to the CCI, patients were divided into high score group(n=25) and low score group(n=26).The patients were divided into the less co-morbidity group(n=24) and more co-morbidity group(n=27) according to co-morbidity numbers.The clinical characteristics, and correlation of number and type of comorbidities with pulmonary function were compared between two groups.
ResultsCompared with the low score group, the age was older, the ratio of FEV1 accounting for expected value was lower, the number of COPD related comorbidities was larger, and the number of hospitalizations was more during 1 year following-up in high score group(P < 0.05 to P < 0.01).Compared with the less co-morbidity group, the age was older, the mMRC score was higher, the ratio of FEV1 accounting for expected value was lower, the CCI score and CCI score after adjusting age were higher, and the treatment course with systemic glucocorticoids and antibiotics because of the COPD acute exacerbating increased during the following-up in more co-morbidity group(P < 0.05 to P < 0.01).There was no statistical significance in the total number of acute exacerbation patients between less co-morbidity group and more co-morbidity group during the following-up(P>0.05).The number of hospital stays and total number of acute exacerbations in patients with COPD complicated with bronchiectasis were higher than those in patients without bronchiectasis(P < 0.05).However, there was no statistically significance among the number of outpatient and community visits, and emergency visits due to exacerbation of COPD(P>0.05).
ConclusionsThe type and disease degree of comorbidities are correlation with the diagnosis and prognosis value in COPD patients.
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