Objective To evaluate the clinical efficacy and safety of tranexamic acid perfusion in the treatment of postoperative bleeding of complex tibial plateau fracture.
Methods Seventy-three patients with complex tibial plateau fracture were randomly divided into the observation group(n=37) and control group(n=36).Two groups were operated by the same surgeon.The incisions in observation group and control group were perfused with tranexamic acid solution and 0.9% sodium chloride injection, respectively.The clinical efficacy and safety between two groups were compared.
Results The total blood loss and hidden blood loss in observation group were less than that in control group(P < 0.05 and P < 0.01), and the difference of the dominant blood loss between two groups was not statistically significant(P>0.05).The postoperative drainage volume and limb diameter in observation group were significantly lower than those in control group(P < 0.01).The ultrasound examination results of lower limb veins showed that there were not severe complications, such as deep venous thrombosis and cardiopulmonary cerebral embolism, in two groups after 10 d of operation.
Conclusions Tranexamic acid perfusion in treating complex tibial plateau fracture can significantly reduce the peroperative blood loss and postoperative drainage volume, do not increase the incidence rate of thrombosis, which is worthy of promotion in clinic.
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