Analysis of the factors influencing the eradication failure of HP

ObjectiveTo analyze the reason of the eradication failure of Helicobacter pylori(HP), and its clinical influencing factors.

MethodsTwo hundred and fifty-seven patients with HP infection were divided into the failure group(77 cases) and cure group(180 cases) according to the eradicating result.The general information and clinical indicators in two groups were collected to analyze the failure causes of eradicating HP.

ResultsThe failure rate of eradicating HP was 29.96%(77/227).The results of univariate analysis showed that the differences of the residence, education level, infection of family members, CagA positive, oral HP infection, treatment status, irregular medication, drug resistance and incomplete supervision between two groups were statistically significant(P < 0.05 to P < 0.01).The results of logistic regression analysis showed that the education level and irregular medication were the independent influencing factors of eradication failure(P < 0.01 and P < 0.05).

ConclusionsA variety of factors, such as cultural level and irregular medication, can affect the eradication results of HP, and the clinical intervention should be conducted as early as possible according to relevant influencing factors.