ObjectiveTo analyze the blood pressure and plasma homocysteine(Hcy) levels in patients with different genotypes of H-type hypertension, and effects of folic acid supplementation on it.
MethodsOne hundred and two H-type hypertension patients treated with routine antihypertension and folic acid therapy(treatment group) were subdivided into the TT group, CT group and CC group according to the genotypes.At the same time, 30 H-type hypertension patients treated with routine antihypertension and without folic acid were set as the control group.The blood pressure and plasma Hcy levels were compared among these groups before and after folic acid treatment.
ResultsThe genotype test in treatment group showed that there were 50 cases(49.02%) in TT group, 28 cases(27.45%) in CT group and 24 cases (23.53%) in CC group.In the control group, 13 cases were TT type(43.33%), 10 cases were CT type(33.33%), and 7 cases were CC type(23.33%).Before treatment, the systolic blood pressure(SBP) level in CC group was significantly higher than that in TT group and control group(P < 0.01), but there was no statistical significance in the levels of diastolic blood pressure(DBP) among all groups(P>0.05). After treatment, the levels of SBP and DBP in treatment group and control group decreased compared with before treatment(P < 0.05), the decreasing degrees of SBP in CC group and CT group were significantly greater than those in TT group and control group, the decreasing degree of DBP level in observation group was greater than that in control group(P < 0.05), and the decreasing degree of DBP level in CC group was greater than that in TT group(P < 0.05).Before treatment, the plasma level of Hcy in TT group was higher than that in CT group, CC group and control group(P < 0.01), and the difference of the serum level of Hcy between CT group and CC group was not statistically significant(P>0.05).After treatment, there was no statistical significance in the level of Hcy among all groups(P>0.05), the levels of Hcy in observation group and control group significantly decreased compared with before treatment(P < 0.01), and the decreasing degree of the level of Hcy in TT group was greater than that in CT group, CC group and control group(P < 0.01).
ConclusionsThere are some differences in blood pressure and plasma Hcy levels in patients with different genotypes of H-type hypertension.The folic acid supplementation combined with conventional antihypertensive drug therapy can further improve the blood pressure and plasma Hcy levels.
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