Study on the correlation between vitamin D level and early 24-hour ambulatory blood pressure changes in patients after PCI

ObjectiveTo investigate the correlation between vitamin D level and early 24-hour dynamic blood parameters in patients after percutaneous coronary intervention(PCI).

MethodsThe clinical data of inpatients with acute myocardial infarction treated with PCI were collected.The level of 25-hydroxyvitamin D25(OH) D was measured at admission.The 24-hour ambulatory blood pressure indicators at admission, and after 1 week and 4 weeks of operation were monitored using the American DMS-ABP ambulatory blood pressure monitor.

ResultsThe normal, insufficient and deficiency levels of 25(OH) D in 26, 21 and 33 patients were identified, respectively.The level of WBC in deficiency group was higher than that in other two groups(P < 0.05), and the level of CRP in normal group was lower than that in other two groups(P < 0.05).The differences of the 24-hour ambulatory blood pressure indictors, which included 24-hour average diastolic blood pressure(24hDBP), daytime average systolic blood pressure(dSBP), daytime average diastolic blood pressure(dDBP) and nighttime diastolic blood pressure(nDBP) in three groups at admission, and after 1 week and 4 weeks of operation were not statistically significant (P>0.05).In addition to the above four indicators, the difference of the 24hSBP in normal group at three time-points was not statistically significant(P>0.05), and the differences of other indictors of the 24-hour ambulatory blood pressure in three groups at three time-points were statistically significant(P < 0.05 to P < 0.01).The results of comparisons between groups showed that the 24-hour ambulatory blood pressure indictors in 25(OH) D deficiency group at each time-point were higher than those in 25(OH) D normal group(P < 0.05).The level of 25(OH) D was negatively correlated with the 24-hour ambulatory blood pressure at admission, and after 1 week and 4 weeks of operation(P < 0.05 to P < 0.01).

ConclusionsThe level of vitamin D is correlated with the changes of 24-hours ambulatory blood pressure after PCI.Therefore, the routine vitamin D supplementation at admission may be beneficial to regulate the blood pressure after PCI, and maintain the 24-hour ambulatory blood pressure balance.