Effect of vildagliptin on the levels of HOMA-IR, hs-CRP, TNF-α and IL-6 in patients with type 2 diabetes mellitus

ObjectiveTo explore the effects of vildagliptin on the levels of insulin resistance index(HOMA-IR), high sensitive C reactive protein(hs-CRP), tumor necrosis factor alpha(TNF-α) and interleukin -6(IL-6) in patients with type 2 diabetes mellitus.

MethodsNinety-six patients with type 2 diabetes mellitus were randomly divided into the control group and observation group(48 cases in each group).The control group was treated with metformin hydrochloride tablets, and the observation group was treated with vildagliptin based on the control group.The levels of fasting blood glucose(FBG), 2 h postprandial blood glucose(2hPBG), glycosylated hemoglobin(HbA1c), fasting insulin (Fins) and HOMA-IR were detected in two groups.

ResultsThe differences of the levels of FBG, 2hPBG, HbA1c, Fins and HOMA-IR between two groups before treatment were not statistically significant(P>0.05).After treatment, these indictors in two groups decreased, the levels of FBG, 2hPBG and HbA1c in control group decreased compared with before treatment(P < 0.01), the levels of FBG, 2hPBG, HbA1c, Fins and HOMR-IR in observation group decreased compared with before treatment, and these indictors in observation group were lower than those in control group(P < 0.01).The differences of the levels of hs-CRP, IL-6and TNF-α between two groups before treatment were not statistically significant(P>0.05).After treatment, the levels of IL-6 and TNF-α in control group significantly decreased compared with before treatment(P < 0.01), the levels of hs-CRP, IL-6 and TNF-α in observation group significantly decreased compared with before treatment, and these indictors in observation group were lower than those in control group(P < 0.01).

ConclusionsVildaglipti can improve the insulin resistance, and significantly reduce the level of inflammatory factors in type 2 diabetic patients, which has high clinical value.