Differential diagnostic value of the combined immunohistochemistry detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocelluar carcinoma and dysplasia

ObjectiveTo investigate the differential diagnostic value of the combined immunohistochemistry detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocelluar carcinoma and dysplasia.

MethodsThe levels of GPC-3, CD10, CD147 and CD138 in 76 cases with highly differentiated hepatocelluar carcinoma and peripheral dysplastic nodules were explored using immunohistochemistry, and the result of which was analyzed.

ResultsCompared with the dysplastic nodules, the levels of GPC-3, CD10 and CD147 in highly differentiated hepatocelluar carcinoma tissue were higher, and these expressions in dysplastic nodules were often disorder and uneven.The expression levels of CD138 in dysplastic nodules and highly differentiated hepatocelluar carcinoma tissue were high and weak or no, respectively.The differences of the levels of GPC-3, CD10, CD147 and CD138 were statistically significant between highly differentiated hepatocelluar carcinoma tissue and dysplastic nodule(P < 0.01).The sensitivities of the combined detection of four markers in highly differentiated hepatocelluar carcinoma tissue and dysplastic nodule were 96.05% and 52.6%, respectively.

ConclusionsThe pathologic differential diagnosis value of the combined detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocellular carcinoma and dysplasia is higher, which can be used as the objective auxiliary indicators between the two in liver biopsy specimens.