Diagnostic value of combined detection of tumor markers and inflammatory markers in non-small cell lung cancer

ObjectiveTo investigate the detection of serum tumor markers carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and inflammatory markers white blood cell (WBC), platelet (PLT), neutrophil (NE), lymphocyte (LY), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of non-small cell lung cancer (NSCLC).

MethodsA total of 147 NSCLC patients (NSCLC group), and 84 healthy people who had physical examination in the same period (control group) were selected.The levels of WBC, PLT, NE, LY, CEA and CYFRA21-1 were measured in two groups, and PLR, NLR were calculated.The differences of the levels or positive rates of the indicators in two groups were compared, and diagnostic efficacy of combined detection in NSCLC was analyzed.

ResultsThe levels of WBC, PLT, NE, NLR, PLR, CEA and CYFRA21-1 in NSCLC group were significantly higher than those in control group, and the LY level was obviously lower than that in control group(P < 0.01).The levels of WBC, NE and CYFRA21-1 of NSCLC patients in stage Ⅲ+Ⅳ were higher than those in stage Ⅰ+Ⅱ(P < 0.05).The level of CEA and CYFRA21-1 in patients with squamous cell carcinoma was lower and higher than that in patients with adenocarcinoma (P < 0.05), respectively.The sensitivity of combined detection of CEA, CYFRA21-1, PLR and NLR in the diagnosis of NSCLC was significantly higher than that of single detection.The diagnostic efficiency of combined detection in NSCLC and early NSCLC was 0.926 and 0.881, respectively.

ConclusionsThe levels of WBC, PLT, NE, LY, CEA, CYFRA21-1, PLR and NLR have certain diagnostic values for NSCLC, and the combined detection of WBC, PLT, NE, LY, CEA, CYFRA21-1, PLR and NLR has higher diagnostic value for NSCLC than a single indicator.