Study on the changes of the inflammatory factors level in patients with bloodstream infection caused by different types of pathogens

ObjectiveTo analyze the changes of the levels of procalcitonin(PCT) and C-reactive protein(CRP) in patients with bloodstream infection(BSI), and explore their clinical value in the diagnosis of BSI.

MethodsThe levels of PCT and CRP between the patients with BSI(BSI group, 43 cases) and other sites infection without BSI(non-BSI group, 43 cases) were compared in the early stage of infection(before treatment), and the ROC curve was drawn to evaluate the clinical value of PCT and CRP in the early diagnosis of BSI.

ResultsThe results of blood culture showed that among the patients with BSI infection, 15 cases were infected with Gram-positive bacteria, accounting for 34.9%, and 28 cases were infected with Gram-negative bacteria, accounting for 65.1%.The main Gram-positive bacterium was Streptococcus, and the main Gram-negative bacterium was Escherichia coli.The levels of PCT and CRP in BSI group were significantly higher than those in non-BSI group in the early infection(P < 0.01), and the levels of PCT and CRP in BSI group were significantly higher than those in Gram-positive bacteria group(P < 0.01).Among different bacteria infection, the area under the ROC curve of PCT and CRP were 0.976 and 0.886, respectively, the specificity of which was 96.4% and 78.6%, respectively, and the sensitivity of which was 86.7% and 94.55%, respectively.

ConclusionsThe detection of PCT and CRP has the early diagnostic value for BSI, and can preliminarily determine the type of pathogens, and guide clinical empirical medication.However, the specific medication scheme needs to be selected according to the clear results of blood culture to improve clinical therapeutic effects.