Effect of sesamin on expression of Toll-like receptor 2 in experimental brain injury

ObjectiveTo investigate the effect of sesamin on the expression of Toll-like receptor 2 (TLR2) in experimental brain injury.

MethodsA model of craniocerebral injury was established using free fall method, and 45 mice were randomly divided into the sham surgery group, craniocerebral injury group and sesamin treatment group after brain trauma.The change of brain edema was observed by measuring the dry and wet weight of brain tissue.The expression level of TLR2 protein in brain tissue of mice was detected using Western blotting.The expression levels of inflammatory factors in tissues surrounding brain injury were detected using real time fluorescence quantitative PCR.

ResultsThe levels of brain water, TLR2 expression and inflammatory factor in craniocerebral injury group were significantly higher than those in sham surgery group (P < 0.05 to P < 0.01).The levels of brain water, TLR2 protein expression and inflammatory factor expression in sesame treatment group were lower than those in craniocerebral injury group (P < 0.05 to P < 0.01).

ConclusionsThe TLR2 expression and inflammatory response in traumatic brain injury brain tissue strengthen, and sesamin can inhibit inflammatory response and protect brain tissue from further injury.