ObjectiveTo analyze the effect of dexmedetomidine on the recovery quality and serum neuron-specific enolase (NSE) and S100β protein levels in patients undergoing neonatal intestinal atresia surgery.
MethodsSixty neonates with intestinal atresia surgery were selected and divided into observation group (n=30) and control group (n=30) according to the random number table method.During the operation, both groups received continuous intravenous infusion of remifentanil and sevoflurane inhalation to maintain anesthesia.After intubation, the observation group received continuous intravenous infusion of dexmedetomidine, and the control group received the same amount of 0.9% sodium chloride solution in the same way.The hemodynamic parametersheart rate (HR), diastolic pressure (DBP), systolic pressure (SBP) and bispectral index (BIS) were compared before anesthesia, 5 min after tracheal intubation, time of incision and extubation.The Ramsay sedation score of preoperation, 3 min, 15 min and 30 min after extubation, the serum level of NSE and S100β protein at preoperation, 6 h, 1 d and 3 d after operation, and the incidence rate of adverse reactions were compared in two groups.
ResultsThe levels of HR, DBP and SBP before anesthesia, 5 min after tracheal intubation, time of incision and extubation in observation group were lower than those in control group (P < 0.05 to P < 0.01).The BIS value at 5 min after tracheal intubation, time of incision and extubation in two groups was lower than that of before anesthesia, and which in observation group was significantly lower than that of control group (P < 0.01).The Ramsay score at 3 min, 15 min and 30 min after extubation in two groups was higher than that of before operation (P < 0.05), and which in observation group was significantly higher than that in control group (P < 0.01).The serum level of NSE and S100β protein at 6 h, 1 d and 3 d after operation in two groups was higher than that of before operation (P < 0.05), and which in observation group was lower than that in control group (P < 0.05 to P < 0.01).The total incidence rate of adverse reactions in observation group (10.00%) was lower than that in control group (33.33%) (P < 0.05).
ConclusionsThe application of dexmedetomidine in anesthesia for neonatal intestinal atresia surgery can improve the BIS value, increase the sedative effect, stabilize the hemodynamics during surgery, improve the quality of postoperative recovery, alleviate the damage to the brain nerve function, and reduce the incidence of adverse reactions.
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