Clinical significance of the levels of D-dimer and fibrinogen in patients with different parts of traumatic fracture

ObjectiveTo detect the levels of D-dimer (D-D) and fibrinogen (FIB) in patients with fracture, and analyze the relationship between the levels of D-D and FIB, and fracture site, severity and deep vein thrombosis (DVT).

MethodsThree hundred and fifty fracture patients were set as the observation group, and subdivided into the group A (ISS ≤ 16 points, n=178), group B (16 points < ISS < 25 points, n=62) and group C (ISS ≥ 25 ponts, n=110) according to the severity of injury.The patients were divided into the DVT group (32 cases) and non-DVT group (318 cases) according to the DVT formation.One hundred health people were set as the control group.The levels of D-D and FIB in observation group and control group were detected.

ResultsCompared with the control group, the levels of D-D and FIB in observation group significantly increased (P < 0.01).The levels of D-D in patients with multiple fractures, spine fracture, tibia and fibula fractures, foot fracture, femoral fracture, humeral fracture, ulna and radius fractures were different, and gradually decreased.The levels of FIB in patients with multiple fractures, tibiofibula fractures, foot bone fracture, spine fracture, humerus fracture, femur fracture and ulnar radius fractures gradually decreased.With the injury aggravating, the levels of D-D and FIB in all cases gradually increased (P < 0.01), and the levels of D-D and FIB in DVT group were significantly higher than those in non-DVT group (P < 0.01).The results of logistic regression analysis showed that the levels of D-D and FIB were correlated with the incidence of DVT (P < 0.01 and P < 0.05).

ConclusionsThe levels of D-D and FIB can help to determine the patient's coagulation condition, severity of disease and incidence of DVT, which is the important indicators of fracture patients.