Analysis of epidemic trend of common multi-drug resistant bacteria in a tertiary hospital

ObjectiveTo study the variation trend of common multi-drug resistant bacteria in a tertiary hospital, and provide the evidence for the rational use of antimicrobial drugs and prevention and control of nosocomial infections.

MethodsThe data of pathogenic bacteria and drug-resistance in a hospital from 2015 to 2017 were retrospectively analyzed, and analyzed using the WHONET5.6 and SPSS20.0 software.

ResultsThe composition ratio of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus in the hospital analyzed an upward trend (P < 0.05 to P < 0.01).The extended-spectrum β-lactamase (ESBLs) Escherichia coli, ESBLs-producing Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, carbapenem-resistant large intestine Escherichia coli, carbapenem-resistant Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii and carbapenem-resistant Pseudomonas aeruginosa were the common multiple drug resistant bacteria in the hospital.Among common multi-drug resistant bacteria from 2015 to 2017, the composition ratio of ESBLs Escherichia coli, carbapenem-resistant Acinetobacter baumannii and ESBLs-producing Klebsiella Pneumoniae, methicillin-resistant Staphylococcus aureus decreased (P < 0.05 to P < 0.01), while the composition ratio of carbapenem-resistant Klebsiella, methicillin-resistant Staphylococcus aureus, and carbapenem-resistant Pseudomonas aeruginosa increased (P < 0.05 to P < 0.01).The drug-resistance of klebsiella Pneumoniae and Pseudomonas aeruginosa to carbapenems increased (P < 0.01).

ConclusionsThe resistance of common pathogens in the hospital is serious.The drug-resistance of Klebsiella pneumoniae and Pseudomonas aeruginosa to carbapenems increases rapidly, the hospital should strengthen the supervision of antimicrobial agents and multi-drug resistant bacteria to control the infection and spread of multi-drug resistant bacteria.