Application value of the tumor-specific growth factor in evaluating the severity of pneumonia

ObjectiveTo investigate the application value of tumor specific growth factor (TSGF) in evaluating the severity of pneumonia, and compare it with the neutrophil (N) -lymphocyte (L) ratio (NLR), hypersensitive C-reactive protein (hs-CRP) and fibrinogen (FIB).

MethodsThe clinical data and laboratory index of 79 pneumonia patients from department of respiratory medicine (pneumonia group) and 40 physical examination people from the physical examination center (control group).According to the scoring system of CURB-65, 79 patients with pneumonia were subdivided into the low-risk pneumonia group (42 cases, CRUB-65 score ≤ 1) and medium-high risk pneumonia group (37 cases, CRUB-65 score ≥ 2).The serum levels of TSGF, hs-CRP, NLR and FIB were detected.The Pearson correlation analysis was used to analyze the correlations between TSGF, and NLR, hs-CRP and FIB, the Spearman correlation analysis was used to analyze the correlation between TSGF and CURB-65 score, and the logistic regression analysis was used to analyze the correlations between TSGF, NLR, hs-CRP, FIB, N, L, age and sex, and severity of pneumonia.The predictive efficacy of the comparison the area under the curve (AUC) of TSGF with NLR, hs-CRP and FIB in the diagnosis of pneumonia was evaluated.

ResultsThe TSGF level in pneumonia patients was significantly higher than that in control group (P < 0.05), the TSGF in low-risk pneumonia patients was significantly higher than that in control group (P < 0.05), and the TSGF level in medium-high risk pneumonia group further increased compared with the low-risk pneumonia group (P < 0.05).The TSGF was positively correlated with the scores of hs-CRP, FIB, NLR and CRUB-65 score (P < 0.05).In the ROC curve for predict pneumonia, the AUC of TSGF was significantly greater than that of NLR, hs-CRP and FIB (P < 0.05).TSGF was significantly correlated with the risk of pneumonia severity increasing (P < 0.01).

ConclusionsTSGF may be a new biomarker for evaluating the severity of pneumonia, which is rapid, with high diagnostic efficiency, easy to analyze, and worthy of clinical application.