Validityan alysis of Caprini thrombosis assessment scale in assessing the risk of venous thromboembolism in liver failure patients treated with artificial liver

ObjectiveTo investigate the validity of the Caprini thrombosis assessment scale in predicting the risk of venous thromboembolism (VTE) in liver failure patients treated with artificial liver.

MethodsOne hundred liver failure patients treated with artificial liver were divided into the VTE group (25 cases) and control group (75 cases without VTE).The clinical data (including medical history, clinical symptoms, treatment plan and laboratory examination) were retrospectively analyzed.The risk scale of Caprini and risk grading of VET were analyzed using the Caprini thrombosis risk assessment scale.The relationship between Caprini score and onset of VTE in liver failure patients treated with artificial liver were analyzed using multivariate logistic regression model.

ResultsThe Caprini score in VTE group (4.280±1.948) was higher than that in control group (2.947±2.155) (P < 0.01), and the risk grading in VTE group was lower than that in control group (P < 0.05).The results of multivariate logistic regression analysis showed that the year > 60 years, bedridden or brake > 72 h, obesity (BMI>25 kg/m²), hormone therapy and lower extremity edema were the major high-risk factors of the onset of VTE in liver failure patients treated with artificial liver.The onset risk of VTE in the extremely high-risk patients was 8.667 times of that in low risk patients.

ConclusionsThe Caprini thrombosis risk assessment scale is a good risk predictor for VTE in liver failure patients treated with artificial liver.