Correlation analysis of the serum levels of cystatin C and uric acid with cognitive impairment in Parkinson's disease

ObjectiveTo investigate the changes of serum levels of cystatin C and uric acid in patients with Parkinson's disease(PD), and analyze the correlation of serum levels of cystatin C and uric acid with cognitive impairment.

MethodsSixty patients with PD and 30 cases healthy examiners matched for gender and age were divided into the observation group(PD group) and control group, respectively.The PD group were subdivided into the PD complicated with cognitive impairment group and PD complicated without cognitive impairment group according to the mini-mental State Examination(MMSE) score.The serum levels of cystatin C and uric acid in all groups were measured.

ResultsThe serum levels of cystatin C and uric acid in PD group were higher and lower than those in control group, respectively(P < 0.05 and P < 0.01).The serum levels of cystatin C and uric acid in PD complicated with cognitive impairment group were higher and lower than those in PD complicated without cognitive impairment group, respectively(P < 0.01 and P < 0.05).The serum level of cystatin C was negatively correlated with MMSE score(P < 0.01), and the serum level of uric acid was positively correlated with MMSE score(P < 0.05).

ConclusionsThe serum levels of cystatin C and uric acid are correlated with PD complicated with cognitive impairment, which can be used as an early biological evaluation index in PD complicated with cognitive impairment.