Study on the drug resistance of bacteria and risk factors of Acinetobacter baumannii caused ventilator-associated pneumonia

ObjectiveTo investigate the drug resistance of Acinetobacter baumannii caused ventilator-associated pneumonia(VAP), and risk factors of VAP.

MethodsThe patients treated with mechanical ventilation from ICU were investigated.Thirty Acinetobacter baumannii infection patients and 30 patients without VAP were divided into the observation group and control group, respectively.The drug resistance of Acinetobacter baumannii and risk factors of VAP were analyzed.

ResultsThe drug resistance rates of Acinetobacter baumannii isolated to amikacin, piperacillin/tazobactam were relatively low, which was 53.3% and 66.6%, respectively.The drug resistance rates of Acinetobacter baumannii to cefazoline, ampicillin, aztreonam, nitrofurantoin and cefotetan were more than 90%, the drug resistance rate of Acinetobacter baumannii to imipenem reached 80%, and the drug resistance rates of Acinetobacter baumannii to other antimicrobia resistance were greater than 70%.The results of univariate analysis showed that the differences of drug resistance in length of hospital stay, mechanical ventilation mode, mechanical ventilation duration, using more than 3 combination of antibiotics before infection, using carbapenems before infection and using enteral nutrition were statistically significant(P < 0.01).The results of logistic analysis showed that the hospitalization time≥14 days, tracheotomy and mechanical ventilation time≥5 days were the independent risk factors of the incidence of Acinetobacter baumannii caused VAP.

ConclusionsThe drug-resistance of Acinetobacter baumannii isolated froun Acinetobacter baumannii caused VAP to antibacterial agents is higher.The antibiotics should be reasonably selected, and the management of nosocomial infection should be strengthened according to the related risk factors.