Study on the early warning effect of serum vitamin D binding protein in acute pancreatitis, and its mechanism

ObjectiveTo analyze the early warning effects of serum vitamin D binding protein(DPB) during the treatment of acute pancreatitis, analyze the possible mechanism for providing a reference in the improvement of acute pancreatitis treatment regimen.

MethodsEighty-six acute pancreatitis patients were divided into the mild group(31 cases), moderate group(30 cases) and severe group(25 case) according to the severity of disease at the time of visit, and 30 healthy people was set as the control group.The DPB at different time periods after treatment were compared among four groups.The degree of organ failure in severe pancreatitis patients or mild and moderate transforming into severe acute pancreatitis patients were evaluated using modified Marshall scoring system, and the DPB levels in different scores patients were compared.

ResultsAmong the acute pancreatitis patients, the DPB level in severe group was significantly lower than that in control group(P < 0.05), and the differences of the DBP levels between the mild and moderate groups, and control group were not statistically significant(P>0.05).The levels of DBP in mild group after 1 and 2 weeks of treatment were higher than that before treatment(P < 0.05 and P < 0.01), and the levels of DBP in moderate and severe groups after 2 weeks of treatment were higher than that before treatment(P < 0.05).The DBP level of patients with Marshall scores 3-4 after 2 weeks of treatment was higher than that of patients with Marshall score 0(P < 0.05).

ConclusionsThe serum level of DPB in acute pancreatitis patients is related to the disease progression, which plays certain role in early warning and has clinical value for further research.