Effect of vacuum sealing drainage technique combined with epidermal growth factor in the treatment of deep burn

ObjectiveTo investigate the effects of vacuum sealing drainage(VSD) technique combined with epidermal growth factor(EGF) in the treatment of deep burn.

MethodsOne hundred patients with deep burn were randomly divided into the control group and observation group(50 cases each group).The wound in two groups was cleaned, and closed with VSD device.The control group was treated with normal saline, and the observation group was treated with EGF solution washing suction device.The wound healing and inflammatory reaction condition were compared between two groups.

ResultsAfter 5 d of treatment, there was no statistical significance in the wound healing rate between two groups(P>0.05), and the levels of interleukin-1 and tumor necrosis factor-α, noradrenaline, epinephrine and rennin in observation group were significantly lower than those in control group(P < 0.01).The wound healing rates in two groups significantly increased after 10 d and 15 d of treatment, and which in observation group was higher than that in control group(P < 0.05).The wound healing time, number of scar healing cases and infection cases in observation group were significantly lower than those in control group(P < 0.05 to P < 0.01).

ConclusionsVSD technique combined with EGF can promote the wound healing in patients with deep burn, improve the healing effect, reduce the patient's inflammatory stress reaction, which is worthy of clinical promotion.