Significance of the combined detection of serum Golgi protein 73, serum ferritin and α-fetoprotein in patients with primary hepatocellular carcinoma

ObjectiveTo analyze the diagnosis value of the combined detection of Golgi protein 73(GP73), serum ferritin(SF) and α-fetoprotein(AFP) in patients with primary hepatocellular carcinoma.

MethodsSeventy-two patients with primary hepatocellular carcinoma and 60 healthy people were divided into the observation group and control group, respectively.The levels of GP73, SF and AFP in two groups were detected, the correlation among three indexes and incidence of primary hepatocellular carcinoma was analyzed using logistic regression analysis.The sensitivity and specificity of separate and combinde detection of three indexes were compared.

ResultsThe levels of GP73, SF and AFP in observation group were significantly higher than those in control group(P < 0.01).The results of regression analysis showed that high levels of GP73, SF and AFP were the risk factors of primary hepatocellular carcinoma(P < 0.05 to P < 0.01).The sensitivity and specificity of GP73, SF and AFP in detecting primary hepatocellular carcinoma were(69.44%, 66.67% and 70.83%) and(96.67%, 91.67% and 95.00%), respectively.The sensitivity and specificity of the combined detection were 98.61% and 83.33%, respectively, which was higher and lower than that in alone index detection, respectively.

ConclusionsGP73, SF and AFP are important serological markers in the diagnosis of primary hepatocellular carcinoma.The combined detection of GP73, SF and AFP significantly improve the sensitivity and specificity of diagnosis compared with the alone index detection.