ObjectiveTo explore the clinical significance of the coagulation parameters, D-dimer (DD) and plasma fibrinogen degradation product(FDP) levels in patients with fractures.
MethodsA total of 57 fracture patients and 68 healthy people were divided into the observation group and control group, respectively.The prothrombin time(PT), activated partial prothrombin time(APTT) and thrombin time(TT), and levels of fibrinogen(Fg), DD and FDP were compared between two groups.Among the patients in observation group with different types of fractures, the positive rates of Fg, DD and FDP, levels of Fg, DD and FDP in patients with and without deep vein thrombosis(DVT) were compared.
ResultsThe levels of Fg, DD and FDP in observation group were significantly higher than those in control group(P < 0.01), the level of TT in observation group was lower than that in control group(P < 0.05), and the differences of the level of PT and APTT between two groups were not statistically significant(P>0.05).The differences of the positive rates of Fg and DD in observation group with different types fracture were not statistically significant(P>0.05), and the difference of the positive rate of FDP in observation group with different types fracture was statistically significant(P < 0.05).Before 1 day of operation, the differences of the levels of Fg, DD and FDP in observation group between patients with and without DVT were not statistically significant(P>0.05).After 7 days of operation, the levels of Fg, DD and FDP in patients with DVT were significantly higher than those in patients without DVT(P < 0.01), and the levels of Fg, DD and FDP in patients with DVT significantly increased compared with before 1 day of operation(P < 0.01).
ConclusionsCoagulation index, DD, FDP can effectively reflect the coagulation function of fracture patients, its sensitivity is high, and it has certain guiding value to prevent the DVT formation in patients.
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