Clinical study of integrated chemotherapy in the treatment of locally advanced gastric cancer in the elderly

ObjectiveTo explore the integrated chemotherapy in the treatment of locally advanced gastric cancer in the elderly.

MethodsSixty elderly cases with locally advanced gastric cancer were randomly divided into observation group and control group (30 cases in each group).The observation group was treated with interventional therapy of 5-fluorouracil 1.0 g/m² plus oxaliplatin 130 mg/m², and oral tegiol 40 mg each time at one week after surgery, bid, for 4 weeks, rest for 2 weeks, which was a cycle.The treatment efficacy was evaluated after two cycles.The control group was treated with oral tegiol following the same dose and course of treatment as the observation group, and oxaliplatin 150 mg/m² was used intravenously.The short-term efficacy, adverse reactions and prognosis in two groups were compared.

ResultsThe objective response rate and disease control rate in observation group were 50.0% and 83.3%, respectively, which were 26.6% and 50.0% in control group, respectively.There was a significant difference in treatment efficacy between two groups (P < 0.01).The adverse reactions in two groups were mostly mild to moderate, and were alleviated after symptomatic treatment, the difference of which was not statistically significant (P>0.05).The median progression-free survival was 17 months, with 95%CI of 16.53 to 25.28 in observation group, which were 13 months and 10.98 to 14.18 in control group, and the survival time in observation group was significantly longer than that in control group (P < 0.01).Univariate analysis showed that the survival time of patients was correlated with the location of tumor, duration of disease, surgery or not, and postchemotherapy (P < 0.05 to P < 0.01), and was not significantly correlated with the gender, pathological type and gross type (P>0.05).Multivariate analysis showed that grouping was an independent prognostic factor (P < 0.01, 95%CI=19.89-21.54).

ConclusionsThe application of integrated chemotherapy in treating locally advanced gastric cancer in elderly patients can improve the prognosis with good safety.