ObjectiveTo investigate the infection rate of human papilloma virus (HPV) among women in Baoshan district of Shanghai and its relationship with age, as well as the distribution of various subtypes, so as to provide the theoretical basis for the prevention and treatment of cervical cancer in this region.
MethodsTwenty-seven HPV genotypes were detected by flow fluorescence hybridization in the samples of cervicalexfoliatedcells from 7 709 women.The relationship between HPV infection rate and age, and the distribution characteristics of HPV subtype infection were analyzed.
ResultsIn the 7 709 cases, 1 237 cases were HPV-positive with the infection rate of 16.05%, and all the 27 HPV subtypes were found.Among them, 833 cases were high-risk genotype with the infection rate of 10.81%, and the top five high-risk genotypes were HPV 52, 16, 53, 58, 39;254 cases were low-risk genotype with the infection rate of 3.29%, and the top five low-risk genotypes were HPV61, 43, 55, 81, 6.HPV infection was mainly distributed in 41-50 and 31-40 years old groups, and the difference of infection rate among different age groups was statistically significant(P < 0.01).In the 1 237 cases with HPV infection, it was mainly the single genotype infection, followed by double infection, and a few multiple infection.
ConclusionsHPV infection is mainly single high-risk genotype, and the common high-risk genotypes are HPV52, 16, 53, 58, 39.The peak age of HPV infection is between 41 and 50 years old.HPV genotype and age should be taken into account in the screening, prevention and treatment of cervical cancer as well as the development and application of vaccines.
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